产品货号：
GS4897
中文名称：
重组人IL-17
英文名称：
Recombinant Human Interleukin-17
产品规格：
5μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 31.0kDa,a disulfide-linked homodimer of two 132 amino acid polypeptide chains.
储存条件：冷冻（-20℃）
概述
Human Interleukin-17A(IL-17A)is encoded by the IL17A gene located on the chromosome 6 and belongs to the IL-17 family that contains IL-17A,IL-17B,IL-17C,IL-17D,IL-17E and IL-17F.They have a similar protein structure,with four highly conserved cysteine residues critical to their 3-dimensional shape,but no sequence similarity to any other known cytokines.Interleukin 17 is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpesvirus Saimiri.Mature IL-17 containing one potential N-linked glycosylation site.Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers.At the amino acid level,IL-17 exhibits 63%amino acid identity with mouse IL-17.High levels of human IL-17 were induced from primary peripheral blood CD4+ T cells upon stimulation and they can induce stromal cells to produce proinflammatory and hematopoietic cytokines.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人IL-17，IL-17, Human，Recombinant Human Interleukin-17
储存条件：冷冻（-20℃）
概述
Human Interleukin-17A(IL-17A)is encoded by the IL17A gene located on the chromosome 6 and belongs to the IL-17 family that contains IL-17A,IL-17B,IL-17C,IL-17D,IL-17E and IL-17F.They have a similar protein structure,with four highly conserved cysteine residues critical to their 3-dimensional shape,but no sequence similarity to any other known cytokines.Interleukin 17 is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpesvirus Saimiri.Mature IL-17 containing one potential N-linked glycosylation site.Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers.At the amino acid level,IL-17 exhibits 63%amino acid identity with mouse IL-17.High levels of human IL-17 were induced from primary peripheral blood CD4+ T cells upon stimulation and they can induce stromal cells to produce proinflammatory and hematopoietic cytokines.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 7.5ng/ml,corresponding to a specific activity of>1.3×105 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rHuIL-17 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in 4mMHCl to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | GITIPRNPGC PNSEDKNFPR TVMVNLNIHN RNTNTNPKRS SDYYNRSTSP WNLHRNEDPE RYPSVIWEAK CRHLGCINAD GNVDYHMNSV PIQQEILVLR REPPHCPNSF RLEKILVSVG CTCVTPIVHH VA |
相关搜索：重组人IL-17，IL-17, Human，Recombinant Human Interleukin-17